Just read this article from Science Daily:
Penn Study Points To How COX-2 Inhibitors Can Eventually Lead To Heart Disease
(excerpt)
Two randomized trials of COX-2 inhibitors–the gold standard of clinical evidence–conducted in 2004 at other institutions suggested that risk of cardiovascular disease might increase gradually during continued treatment with drugs such as Celebrex and Vioxx, even in individuals initially at low risk of the disease.
“The risk of heart attack and stroke became progressively evident during treatment with either Celebrex or Vioxx during the APPROVe and APC trials last year,” says Garret FitzGerald, MD, lead author of the study published online last week. FitzGerald is the Director of the Institute for Translational Medicine and Therapeutics at Penn.
My doc just put me on a new NSAID called Mobic which is not a COX-2 inhibitor but still is for osteoarthritis. I miss my Vioxx but even I am rethinking the pro vs con.